The English women defeated the Indian women with eight cassettes in the first ODI, which took a 1-0 lead in a series of three games here on Sunday.
Placed on the bat, India Women scored 201 for eight. Skipper Mitali Raj scored the most with 72 taps with 72 balls, while Punam Raut made 32.
For England women, Sophie Ecclestone (3/40) was selected by bowling, while Anya Shrubsole (2/33) and Catherine Brant (2/35) shared four goals.
Tammy Beaumont (87 not out) and Nat Skiver (74 not out) hit a fast half-century, while the English women comfortably chased the goal in 34.5 overs.
India women: 201 for eight out of 50 overs (Mithali Raj 72; Sophie Ecclestone 3/40).
England Women: 202 for 2 in 34.5 over (Tammy Beaumont 87 is not out, Nat Sciver 74 is not out; Jhulan Goswami 1/25).